1980s
Wong A, Kean L, Maurer R. Sequence of the dnaB gene of Salmonella typhimurium. Journal of bacteriology. 1988 Jun 1; 170(6): 2668-75. PubMed PMID: 2836367; PubMed Central PMCID: PMC211186.
1990s
Kean LS, Fuller RS, Nichols JW. Retrograde lipid traffic in yeast: identification of two distinct pathways for internalization of fluorescent-labeled phosphatidylcholine from the plasma membrane. The Journal of cell biology. 1993 Dec 1; 123(6 Pt 1): 1403-19. PubMed PMID: 8253840; PubMed Central PMCID: PMC2290883.
Kean LS, Grant AM, Angeletti C, Mahé Y, Kuchler K, Fuller RS, Nichols JW. Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. The Journal of cell biology. 1997 Jul 28; 138(2): 255-70. PubMed PMID: 9230069; PubMed Central PMCID: PMC2138184.
Olney PN, Kean LS, Graham D, Elsas LJ, May K. Campomelic syndrome and deletion of SOX9. American journal of medical genetics. 1999 May 7; 84(1): 20-4. PubMed PMID: 10213041.
Adams AB, Durham MM, Kean L, Shirasugi N, Ha J, Williams MA, Rees PA, Cheung MC, Mittelstaedt S, Bingaman AW, Archer DR, Pearson TC, Waller EK, Larsen CP. Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression. Journal of immunology (Baltimore, Md. : 1950). 2001 Jul 15; 167(2): 1103-11. PubMed PMID: 11441122.
Kean LS, Durham MM, Adams AB, Hsu LL, Perry JR, Dillehay D, Pearson TC, Waller EK, Larsen CP, Archer DR. A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation. Blood. 2002 Mar 1; 99(5): 1840-9. PubMed PMID: 11861303.
Kean LS, Brown LE, Nichols JW, Mohandas N, Archer DR, Hsu LL. Comparison of mechanisms of anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposure. Experimental hematology. 2002 May 1; 30(5): 394-402. PubMed PMID: 12031645.
Kean LS, Manci EA, Perry J, Balkan C, Coley S, Holtzclaw D, Adams AB, Larsen CP, Hsu LL, Archer DR. Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease. Blood. 2003 Dec 15; 102(13): 4582-93. PubMed PMID: 12933586.
Roberts C, Kean L, Archer D, Balkan C, Hsu LL. Murine and math models for the level of stable mixed chimerism to cure beta-thalassemia by nonmyeloablative bone marrow transplantation. Annals of the New York Academy of Sciences. 2005 Jan 1; 1054: 423-8. PubMed PMID: 16339691.
Kean LS, Adams AB, Strobert E, Hendrix R, Gangappa S, Jones TR, Shirasugi N, Rigby MR, Hamby K, Jiang J, Bello H, Anderson D, Cardona K, Durham MM, Pearson TC, Larsen CP. Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007 Feb 1; 7(2): 320-35. PubMed PMID: 17241112.
Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW. Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation. 2007 Jul 27; 84(2): 196-206. PubMed PMID: 17667811.
Hamby K, Trexler A, Pearson TC, Larsen CP, Rigby MR, Kean LS. NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007 Aug 1; 7(8): 1884-96. PubMed PMID: 17617852.
Kean LS, Grant AM, Angeletti C, Mahé Y, Kuchler K, Fuller RS, Nichols JW. Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. The Journal of cell biology. 1997 Jul 28; 138(2): 255-70. PubMed PMID: 9230069; PubMed Central PMCID: PMC2138184.
Olney PN, Kean LS, Graham D, Elsas LJ, May K. Campomelic syndrome and deletion of SOX9. American journal of medical genetics. 1999 May 7; 84(1): 20-4. PubMed PMID: 10213041.
Adams AB, Durham MM, Kean L, Shirasugi N, Ha J, Williams MA, Rees PA, Cheung MC, Mittelstaedt S, Bingaman AW, Archer DR, Pearson TC, Waller EK, Larsen CP. Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression. Journal of immunology (Baltimore, Md. : 1950). 2001 Jul 15; 167(2): 1103-11. PubMed PMID: 11441122.
Kean LS, Durham MM, Adams AB, Hsu LL, Perry JR, Dillehay D, Pearson TC, Waller EK, Larsen CP, Archer DR. A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation. Blood. 2002 Mar 1; 99(5): 1840-9. PubMed PMID: 11861303.
Kean LS, Brown LE, Nichols JW, Mohandas N, Archer DR, Hsu LL. Comparison of mechanisms of anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposure. Experimental hematology. 2002 May 1; 30(5): 394-402. PubMed PMID: 12031645.
Kean LS, Manci EA, Perry J, Balkan C, Coley S, Holtzclaw D, Adams AB, Larsen CP, Hsu LL, Archer DR. Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease. Blood. 2003 Dec 15; 102(13): 4582-93. PubMed PMID: 12933586.
Roberts C, Kean L, Archer D, Balkan C, Hsu LL. Murine and math models for the level of stable mixed chimerism to cure beta-thalassemia by nonmyeloablative bone marrow transplantation. Annals of the New York Academy of Sciences. 2005 Jan 1; 1054: 423-8. PubMed PMID: 16339691.
Kean LS, Adams AB, Strobert E, Hendrix R, Gangappa S, Jones TR, Shirasugi N, Rigby MR, Hamby K, Jiang J, Bello H, Anderson D, Cardona K, Durham MM, Pearson TC, Larsen CP. Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007 Feb 1; 7(2): 320-35. PubMed PMID: 17241112.
Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW. Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation. 2007 Jul 27; 84(2): 196-206. PubMed PMID: 17667811.
Hamby K, Trexler A, Pearson TC, Larsen CP, Rigby MR, Kean LS. NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007 Aug 1; 7(8): 1884-96. PubMed PMID: 17617852.
2000s
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Kean LS, Adams AB, Strobert E, Hendrix R, Gangappa S, Jones TR, Shirasugi N, Rigby MR, Hamby K, Jiang J, Bello H, Anderson D, Cardona K, Durham MM, Pearson TC, Larsen CP. Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007 Feb 1; 7(2): 320-35. PubMed PMID: 17241112.
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Anderson A, Martens CL, Hendrix R, Stempora LL, Miller WP, Hamby K, Russell M, Strobert E, Blazar BR, Pearson TC, Larsen CP, Kean LS. Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2008 Nov 1; 8(11): 2252-64. PubMed PMID: 18801023; PubMed Central PMCID: PMC2874242.
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Kanthaswamy S, Capitanio JP, Dubay CJ, Ferguson B, Folks T, Ha JC, Hotchkiss CE, Johnson ZP, Katze MG, Kean LS, Kubisch HM, Lank S, Lyons LA, Miller GM, Nylander J, O'Connor DH, Palermo RE, Smith DG, Vallender EJ, Wiseman RW, Rogers J. Resources for genetic management and genomics research on non-human primates at the National Primate Research Centers (NPRCs). Journal of medical primatology. 2009 Oct 1; 38 Suppl 1: 17-23. PubMed PMID: 19863674.
2010-2015
Miller WP, Srinivasan S, Panoskaltsis-Mortari A, Singh K, Sen S, Hamby K, Deane T, Stempora L, Beus J, Turner A, Wheeler C, Anderson DC, Sharma P, Garcia A, Strobert E, Elder E, Crocker I, Crenshaw T, Penedo MC, Ward T, Song M, Horan J, Larsen CP, Blazar BR, Kean LS. GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression. Blood. 2010 Dec 9; 116(24): 5403-18. PubMed PMID: 20833977; PubMed Central PMCID: PMC3012549.
Hendrickson JE, Hod EA, Perry JR, Ghosh S, Chappa P, Adisa O, Kean LS, Ofori-Acquah SF, Archer DR, Spitalnik SL, Zimring JC. Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell disease. Transfusion. 2012 Feb 1; 52(2): 231-40. PubMed PMID: 21790627; PubMed Central PMCID: PMC3218203.
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Ramakrishnan SK, Page A, Farris, 3rd AB, Singh K, Leopardi F, Hamby K, Sen S, Polnett A, Deane T, Song M, Stempora L, Strobert E, Kirk AD, Larsen CP, Kean LS. Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2012 Jul 1; 12(7): 1755-64. PubMed PMID: 22642491; PubMed Central PMCID: PMC3387328.
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Kean LS, Singh K, Blazar BR, Larsen CP. Nonhuman primate transplant models finally evolve: detailed immunogenetic analysis creates new models and strengthens the old. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2012 Apr 1; 12(4): 812-9. PubMed PMID: 22177005; PubMed Central PMCID: PMC3482466.
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Kaliyaperumal S, Watkins B, Sharma P, Furlan S, Ramakrishnan S, Giver C, Garcia A, Courtney C, Knight H, Strobert E, Elder E, Crenshaw T, Blazar BR, Waller EK, Westmoreland S, Kean LS. CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis. Blood. 2014 Mar 20; 123(12): 1967-9. PubMed PMID: 24652969; PubMed Central PMCID: PMC3962171.
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Koura DT, Horan JT, Langston AA, Qayed M, Mehta A, Khoury HJ, Harvey RD, Suessmuth Y, Couture C, Carr J, Grizzle A, Johnson HR, Cheeseman JA, Conger JA, Robertson J, Stempora L, Johnson BE, Garrett A, Kirk AD, Larsen CP, Waller EK, Kean LS. In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013 Nov 1; 19(11): 1638-49. PubMed PMID: 24047754.
Beus JM, Hashmi SS, Selvaraj SA, Duan D, Stempora LL, Monday SA, Cheeseman JA, Hamby KM, Speck SH, Larsen CP, Kirk AD, Kean LS. Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. PloS one. Forthcoming 2013; 8(8): e71221. PubMed PMID: 23940724; PubMed Central PMCID: PMC3733932.
Singh K, Stempora L, Harvey RD, Kirk AD, Larsen CP, Blazar BR, Kean LS. Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2014 Dec 1; 14(12): 2691-703. PubMed PMID: 25359003; PubMed Central PMCID: PMC4236286.
Nickel RS, Horan JT, Fasano RM, Meyer E, Josephson CD, Winkler AM, Yee ME, Kean LS, Hendrickson JE. Immunophenotypic parameters and RBC alloimmunization in children with sickle cell disease on chronic transfusion. American Journal of Hematology. 2015 Dec 1; 90(12): 1135-41. PubMed PMID: 26361243.Saha A, O'Connor RS,
Kaliyaperumal S, Watkins B, Sharma P, Furlan S, Ramakrishnan S, Giver C, Garcia A, Courtney C, Knight H, Strobert E, Elder E, Crenshaw T, Blazar BR, Waller EK, Westmoreland S, Kean LS. CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis. Blood. 2014 Mar 20; 123(12): 1967-9. PubMed PMID: 24652969; PubMed Central PMCID: PMC3962171.
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Singh K, Stempora L, Harvey RD, Kirk AD, Larsen CP, Blazar BR, Kean LS. Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2014 Dec 1; 14(12): 2691-703. PubMed PMID: 25359003; PubMed Central PMCID: PMC4236286.
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Nickel RS, Hendrickson JE, Yee MM, Bray RA, Gebel HM, Kean LS, Miklos DB, Horan JT. Red blood cell transfusions are associated with HLA class I but not H-Y alloantibodies in children with sickle cell disease. British Journal of Haematology. 2015 Jul 1; 170(2): 247-56. PubMed PMID: 25891976; PubMed Central PMCID: PMC4490004.
Stenger EO, Chiang KY, Haight A, Qayed M, Kean L, Horan J. Use of Alefacept for Preconditioning in Multiply Transfused Pediatric Patients with Nonmalignant Diseases. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. 2015 Oct 1; 21(10): 1845-52. PubMed PMID: 26095669; PubMed Central PMCID: PMC5256634.
Kirk AD, Guasch A, Xu H, Cheeseman J, Mead SI, Ghali A, Mehta AK, Wu D, Gebel H, Bray R, Horan J, Kean LS, Larsen CP, Pearson TC. Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2014 May 1; 14(5): 1142-51. PubMed PMID: 24684552; PubMed Central PMCID: PMC4642731.
Suessmuth Y, Mukherjee R, Watkins B, Koura DT, Finstermeier K, Desmarais C, Stempora L, Horan JT, Langston A, Qayed M, Khoury HJ, Grizzle A, Cheeseman JA, Conger JA, Robertson J, Garrett A, Kirk AD, Waller EK, Blazar BR, Mehta AK, Robins HS, Kean LS. CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire. Blood. 2015 Jun 18; 125(25): 3835-50. PubMed PMID: 25852054; PubMed Central PMCID: PMC4473113.
Stenger EO, Chiang KY, Haight A, Qayed M, Kean L, Horan J. Use of Alefacept for Preconditioning in Multiply Transfused Pediatric Patients with Nonmalignant Diseases. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. 2015 Oct 1; 21(10): 1845-52. PubMed PMID: 26095669; PubMed Central PMCID: PMC5256634.
Nickel RS, Osunkwo I, Garrett A, Robertson J, Archer DR, Promislow DE, Horan JT, Hendrickson JE, Kean LS. Immune parameter analysis of children with sickle cell disease on hydroxycarbamide or chronic transfusion therapy. British journal of haematology. 2015 May 1; 169(4): 574-83. PubMed PMID: 25753210; PubMed Central PMCID: PMC4668585.
2016-Present
Thangavelu G, Lovitch SB, Dandamudi DB, Wilson C, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor P, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, et al. (35 authors). Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. The Journal of Clinical Investigation. 2016 Jul 1; 126(7): 2642-60. PubMed PMID: 27294527; PubMed Central PMCID: PMC4922691
Kean L,Turka L, Blazar B. Advances in Targeting Co-inhibitory and Co-stimulatory Pathways in Transplantation Settings: The Yin to the Yang of Cancer Immunotherapy. Immunol Review. 2016 Nov.
Furlan SN, Watkins B, Tkachev V, Cooley S, Panoskaltsis-Mortari A, Betz K, Brown M, Hunt DJ, Schell JB, Zeleski K, Yu A, Giver CR, Waller EK, Miller JS, Blazar BR, Kean LS. Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells. Blood. 2016 Nov 24; 128(21): 2568-2579. PubMed PMID: 27758873; PubMed Central PMCID: PMC5123196.
Hippen KL, Watkins B, Tkachev V, Lemire AM, Lehnen C, Riddle MJ, Singh K, Panoskaltsis-Mortari A, Vanhove B, Tolar J, Kean LS, Blazar BR. Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease. Transplantation. 2016 Dec 1; 100(12): 2630-2639. PubMed PMID: 27861291; PubMed Central PMCID: PMC5175408.
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Zheng HB, Watkins B, Tkachev V, Yu S, Tran D, Furlan S, Zeleski K, Singh K, Hamby K, Hotchkiss C, Lane J, Gumber S, Adams AB, Cendales L, Kirk AD, Kaur A, Blazar BR, Larsen CP, Kean LS. The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques. American Journal of Transplantation. 2017 Mar 1; 17(3): 657-670. PubMed PMID: 27500470; PubMed Central PMCID: PMC5338742.
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Perales MA, Kebriaei P, Kean LS, Sadelain M. Building a Safer and Faster CAR: Seatbelts, Airbags, and CRISPR. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. 2018 Jan 24; 24(1): 27-31. PubMed PMID: 29032264.
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Kean LS. Defining success with cellular therapeutics: the current landscape for clinical endpoint and toxicity analysis. Blood. 2018 Jun 14. PubMed PMID: 29728399.
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Taraseviciute A, Tkachev V, Ponce R, Turtle CJ, Snyder JM, Liggitt HD, Myerson D, Gonzalez-Cuyar L, Baldessari A, English C, Yu A, Zheng H, Furlan SN, Hunt DJ, Hoglund V, Finney O, Brakke H, Blazar BR, Berger C, Riddell S, Gardner R, Kean LS, Jensen MC. Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Non-Human Primates. Cancer Discovery. 2018 Jun 28. PubMed PMID: 29563103.
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Colonna L, Peterson C, Schelle J, Carlson J, Tkachev V, Brown M, Yu A, Reddy S, Obenza W, Nelson V, Polacino P, Mack H, Hu S, Zeleski K, Hoffman M, Olvera J, Furlan S, Zheng H, Taraseviciute A, Hunt D, Betz K, Lane J, Vogel K, Hotchkiss C, Motas C, Baldessari A, Murnane R, English C, Astley C, Wangari S, Agricola B, Athens J, Iwavama N, May A, Stensland L, Huang M, Jerome K, Kiem H, Kean L. Evidence for Persistence of the SHIV Reservoir in Multiple Tissues Early After MHC Haplo-identical Hematopoietic Stem Cell Transplantation. Nature Communications. 2018 Oct 25.
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Andermann TM, Peled JU, Ho C, Reddy P, Riches M, Storb R, Teshima T, van den Brink MRM, Alousi A, Balderman S, Chiusolo P, Clark WB, Holler E, Howard A, Kean LS, Koh AY, McCarthy PL, McCarty JM, Mohty M, Nakamura R, Rezvani K, Segal BH, Shaw BE, Shpall EJ, Sung AD, et al. (32 authors). The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. 2018 Jul 24. PubMed PMID: 29471034.
Allen CE, Marsh R, Dawson P, Bollard CM, Shenoy S, Roehrs P, Hanna R, Burroughs L, Kean L, Talano JA, Schultz KR, Pai S, Baker KS, Andolina JR, Stenger EO, Connelly J, Ramirez A, Bryant C, Eapen M, Pulsipher MA. Reduced-intensity conditioning for hematopoietic cell transplant for HLH and primary immune deficiencies. Blood. 2018 Sep 27; 132(13): 1438-1451. PubMed PMID: 29997222; PubMed Central PMCID: PMC6161764.
Tkachev V, Furlan SN, Watkins B, Hunt DJ, Zheng HB, Panoskaltsis-Mortari A, Betz K, Brown M, Schell JB, Zeleski K, Yu A, Kirby I, Cooley S, Miller JS, Blazar BR, Casson D, Bland-Ward P, Kean LS. Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant. Science Translational Medicine. 2017 Sep 20; 9(408). PubMed PMID: 28931653; PubMed Central PMCID: PMC5681253.
Hippen KL, O'Connor RS, Lemire AM, Saha A, Hanse EA, Tennis NC, Merkel SC, Kelekar A, Riley JL, Levine B, June CH, Turka LA, Kean LS, MacMillan ML, Miller JS, Wagner JE, Munn DH, Blazar BR. In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines. American journal of Transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2017 Dec 1; 17(12): 3098-3113. PubMed PMID: 28470889; PubMed Central PMCID: PMC5671378.
Watkins B, Tkachev, Furlan S, Hunt D, Betz K, Yu A, Brown M, Poirier N, Zheng B, Taraseviciute A, Colonna L, Mary C, Blancho G, Soulillou J, Panoskaltsis-Mortari A, Sharma P, Garcia A, Strobert, Hamby K, Garrett A, Deane T, Blazar B, Vanhove B, Kean L. Systems Analysis of CD28 versus CD80/86 Blockade for GVHD Prevention. Journal of Clinical Investigation. Forthcoming 2018
Watkins BK, Tkachev V, Furlan SN, Hunt DJ, Betz K, Yu A, Brown M, Poirier N, Zheng HB, Taraseviciute A, Colonna L, Mary C, Blancho G, Soulillou JP, Panoskaltsis-Mortari A, Sharma P, Garcia A, Strobert E, Hamby K, Garrett A, Deane T, Blazar BR, Vanhove B, Kean LS. CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates. The Journal of clinical investigation. 2018 Aug 31; 128(9): 3991-4007. PubMed PMID: 30102255; PubMed Central PMCID: PMC6118599.
Pennell C, Barnum J, McDonald-Hyman C, Panoskaltsis-Mortari A, Riddle M, Xiong Z, Loschi M, Thangavelu G, Campbell H, Storlie M, Refaeli Y, Furlan S, Jensen M, Kean L, Miller J, Tolar J, Osborn M, Blazar B. Human CD19-Targeted Mouse T-cells Induce B-Cell Aplasia and Toxicity in Human CD19 Transgenic Mice. Molecular Therapy. 2018 Apr 7. Available from: https://www.sciencedirect.com/science/article/pii/S1525001618301631.
Abraham AA, Lang H, Meier ER, Nickel RS, Dean M, Lawal N, Speller-Brown B, Wang Y, Kean L, Bollard CM. Characterization of natural killer cells expressing markers associated with maturity and cytotoxicity in children and young adults with sickle cell disease. Pediatric blood & cancer. 2019 May 1; 66(5): e27601. PubMed PMID: 30609269.
Uchida N, Nassehi T, Drysdale CM, Gamer J, Yapundich M, Bonifacino AC, Krouse AE, Linde N, Hsieh MM, Donahue RE, Dunbar CE, Kean LS, Tisdale JF. Busulfan combined with immunosuppression allows efficient engraftment of gene-modified cells in a rhesus macaque model. Mol Ther. 2019 Sep 4;27(9):1586-1596
Furlan SN , Singh K , Lopez C, Tkachev V , Hunt D, Hibbard J, Betz KM, Blazar BR, Trapnell C, Kean LS. 2020 IL2 enhances ex-vivo expanded regulatory T cell persistence after adoptive transfer Blood Advances, 2020 Apr 28;4(8):1594-1605.
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM. A Phase I study of sirolimus in combination withmetronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors. Pediatr Blood Cancer. 2020 Apr;67(4):e28134. doi: 10.1002/pbc.28134. Epub 2019 Dec 25.
Radtke S, Colona L, Perez AM, Hoffman M, Kean LS, Kiem H-P (dual-senior author). Allogeneic transplantation of a highly-purified HSC-enriched CD34+CD90+CD45RA– cell subset in the nonhuman primate large-animal model. 2020 Transplantation Direct in pres
Carly G. K. Ziegler, Samuel J. Allon Sarah K. Nyquist, Ian M. Mbano, Vincent N. Miao, Constantine N. Tzouanas, Yuming Cao, Ashraf S. Yousif , Julia Bals , Blake M. Hauser, Jared Feldman, Christoph Muus, Marc H. Wadsworth II, Samuel W. Kazer, Travis K. Hughes, Benjamin Doran, G. James Gatter, Marko Vukovic, Faith Taliaferro, Benjamin E. Mead, Zhiru Guo , Jennifer P. Wang, Delphine Gras, Magali Plaisant , Meshal Ansari , Ilias Angelidis , Heiko Adler , Jennifer M.S. Sucre , Chase J. Taylor , Brian Lin, Avinash Waghray , Vanessa Mitsialis, Daniel F. Dwyer, Kathleen M. Buchheit, Joshua A. Boyce, Nora A. Barrett, Tanya M. Laidlaw, Shaina L. Carroll, Lucrezia Colonna, Victor Tkachev , Christopher W. Peterson , Alison Yu , Hengqi Betty Zheng , Hannah P. Gideon , Caylin G. Winchell, Philana Ling Lin , Colin D. Bingle , Scott B. Snapper , Jonathan A. Kropski , Fabian J. Theis , Herbert B. Schiller , Laure-Emmanuelle Zaragosi , Pascal Barbry Alasdair Leslie, Hans-Peter Kiem , JoAnne L. Flynn , Sarah M. Fortune , Bonnie Berger , Robert W. Finberg , Leslie S. Kean, Manuel Garber, Aaron G. Schmidt, Daniel Lingwood , Alex K. Shalek, Jose Ordovas-Montanes, HCA Lung Biological Network. 2020 SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035.
Mitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Vukovic M, Spencer D, Field M, McCourt C, Toothaker J, Bousvaros A; BCH IBD Center; BWH Crohn’s and Colitis Center, Shalek AK, Kean L, Horwitz B, Goldsmith J, Tseng G, Snapper SB, Konnikova L.2020 Single-cell analysis of colon and blood reveal distinct immune cell signatures of ulcerative colitis and Crohn’s Disease. Gastroenterology. 2020 Aug;159(2):591-608.e10. doi: 10.1053/j.gastro.2020.04.074
Schoettler M, Lehmann LE, Margossian S, Lee M, Kean LS, Kao PC, Ma C, Duncan CN.Risk factors for transplant-associated thrombotic microangiopathy and mortality in a pediatric cohort. Blood Advances. 2020 Jun 9;4(11):2536-2547. doi: 10.1182/bloodadvances.2019001242.
Rust BJ, Kean LS, Colonna L, Brandenstein K, Poole NH, Obenza W, Enstrom MR, Maldini CR, Ellis GI, Fennessey CM, Huang ML, Keele BF, Jerome K, Riley JL, Kiem HP, Peterson CW. Robust Expansion of HIV CAR T Cells Following Antigen Boosting in ART-Suppressed Nonhuman Primates. Blood. 2020 Jul 2:blood.2020006372. doi: 10.1182/blood.2020006372.
Thangavelu G, Wang C, Loschi M, Saha A, Osborn M, Furlan SN, Aoyama K, McDonald-Hyman C, Aguilar EG, Janesick AS, Chandraratna RA, Refaeli Y, Panoskaltsis-Mortari A, MacDonald KP, Hill GR, Zeiser R, Maillard I, Serody J, Murphy WJ, Munn DH, Blumberg B, Brown C, Kuchroo VK, Kean LS, Hippen K, Noelle RJ, Blazar BR. Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses. Blood 2020 Sep 24:blood.2020005628. doi: 10.1182/blood.2020005628. Online ahead of print. PMID: 32976550
Hill GR, Betts BC, Tkachev V, Kean LS* and Blazar BR (Co-Senior Author). 2020. Current Concepts and Advances in Graft-Versus-Host Disease Immunology. Annual Reviews of Immunology In Press
Krienen FM, Goldman M, Zhang Q, del Rosario R, Florio M, Machold R, Saunders A, Levandowski K, Zaniewski H, Schuman B, Wu C, Lutservitz A, Mullally C, Reed N, Bien E, Bortolin L, Fernandez-Otero M, Lin J, Wysoker A, Nemesh J, Kulp D, Burns M, Tkachev V, Smith R, Walsh CA, Dimidschstein J, Kean LS, Berretta S, Fishell G, Feng G, McCarroll SA. 2020. Innovations in Primate Interneuron Repertoire. Nature In press
Potter EL, Gideon HP, Tkachev V,Fabozzi G, Chassiakos A, Petrovas C, Darrah PA, Lin PL, Foulds KE, Kean LS, Flynn JL, Roederer M. 2020. Measurement of Leukocyte Trafficking Kinetics in Macaques by Serial Intravascular Staining Science Translational Medicine In Press
Tkachev V, Kaminski J, Potter EL, Furlan S, Yu, A, Hunt DJ, McGuckin C, Zheng, H, Colonna L, Gerdemann U, Carlson J, Hoffman M, Olvera J, English C, Baldessari A, Panoskaltsis-Mortari A, Watkins B, Qayed M, Suessmuth Y, Betz K, Bratrude B, Langston A, Horan J, Ordovas-Montanes J, Shalek AK, Blazar BR, Roederer M, Kean LS. 2020. Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states. BioRXiv doi: https://doi.org/10.1101/2020.07.20.212399 and Science Translational Medicine In press
Watkins B, Qayed M, McCracken C, Bratrude B, Betz K, Suessmuth Y, Yu A, Sinclair S, Furlan S, Bosinger S, Tkachev V, Rhodes J, Tumlin AG, Narayan A, Cribbin K, Gillespie S, Gooley TA, Pasquini MC, Hebert K, Kapoor U, Rogatko A, Tighiouart M, Kim S, Bresee C, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Norkin M, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR2, Yanik GA, Waller EK, Levine JE, Ferrara JL, Blazar BR, Langston A, Horan JT, and Kean LS. 2020 A Phase 2 Trial of Costimulation Blockade with Abatacept for Prevention of Acute GVHD. Journal of Clinical Oncology in press
Dr. Kean’s complete publication list is found at this URL: http://www.ncbi.nlm.nih.gov/sites/myncbi/18meR_QLJovkO/bibliography/47978032/public/?sort=date&direction=ascending
